In Twisted Web through 19.10.0, there was an HTTP request splitting vulnerability. When presented with two content-length headers, it ignored the first header. When the second content-length value was set to zero, the request body was interpreted as a pipelined request.
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H
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